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Asthma & COPD PYM60001

Asthma is a  chronic inflammatory disorder of the airways that causes recurrent episodes of wheezing, breathlessness, chest tightness and coughing. In addition, asthma is usually associated with widespread but variable airflow obstruction. Inhibition of inflammation and opening of the airways are therefore key components of asthma and chronic obstructive pulmonary disease (COPD)

Mode of action

The Company has identified a series of compounds as potential treatments for COPD and asthma. The lead candidates are TRPV1-modulators, anti-inflammatories and airway relaxants and these prevent airways remodelling and have been tested in several models of asthma. Preclinical comparative proof of concept studies with marketed products have demonstrated encouraging results showing improved beneficial effects in several models of asthma. .

Progress to date

Further work in this area will be initiated as resources allow